| Product name: |
DC-LAMP rabbit pAb |
| Reactivity: |
Human;Rat;Mouse; |
| Alternative Names: |
Lysosome-associated membrane glycoprotein 3 (LAMP-3;Lysosomal-associated membrane protein 3;DC-lysosome-associated membrane glycoprotein;DC LAMP;Protein TSC403;CD antigen CD208) |
| Source: |
Rabbit |
| Dilutions: |
WB 1:500-2000,IHC-p 1:500-200, ELISA 1:10000-20000 |
| Immunogen: |
Synthetic peptide from human protein at AA range: 261-310 |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
44kD |
| GeneID: |
27074 |
| Human Swiss-Prot No: |
Q9UQV4 |
| Cellular localization: |
Cell surface . Lysosome membrane ; Single-pass type I membrane protein . Cytoplasmic vesicle membrane ; Single-pass type I membrane protein . Early endosome membrane ; Single-pass type I membrane protein . During dendritic cell maturation, detected on cytoplasmic vesicles (the MHC II compartment) that contain MHC II proteins, LAMP1, LAMP2 and LAMP3 (PubMed:9768752). Detected on lysosomes in mature dendritic cells (PubMed:9768752). . |
| Background: |
Dendritic cells (DCs) are the most potent antigen-presenting cells. Immature DCs efficiently capture antigens and differentiate into interdigitating dendritic cells (IDCs) in lymphoid tissues that induce primary T-cell responses (summary by de Saint-Vis et al., 1998 [PubMed 9768752]).[supplied by OMIM, Dec 2010], |
