| Product name: |
EDA rabbit pAb |
| Reactivity: |
Human;Mouse |
| Alternative Names: |
EDA; ED1; EDA2; Ectodysplasin-A; Ectodermal dysplasia protein; EDA protein |
| Source: |
Rabbit |
| Dilutions: |
Western Blot: 1/500 – 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000. Not yet tested in other applications. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the Internal region of human EDA. AA range:120-170 |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
42kD |
| GeneID: |
1896 |
| Human Swiss-Prot No: |
Q92838 |
| Cellular localization: |
Cell membrane ; Single-pass type II membrane protein .; [Ectodysplasin-A, secreted form]: Secreted . |
| Background: |
The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene. [provided by RefSeq, Jul 2008], |
