| Product name: |
GABA A Receptor 4 rabbit pAb |
| Reactivity: |
Human;Rat;Mouse |
| Alternative Names: |
GABRA4; Gamma-aminobutyric acid receptor subunit alpha-4; GABA(A) receptor subunit alpha-4 |
| Source: |
Rabbit |
| Dilutions: |
WB 1:1000-2000, IHC 1:100-200 |
| Immunogen: |
Synthetic Peptide of GABA A Receptor 4 AA range: 149-199 |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
62kD |
| GeneID: |
2557 |
| Human Swiss-Prot No: |
P48169 |
| Cellular localization: |
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. |
| Background: |
Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1). Alternatively spliced transcript variants encoding different isoforms have been found in this gene.[provided by RefSeq, Feb 2011], |
