| Product name: |
IGF-I Receptor (phospho-Tyr980) rabbit pAb |
| Reactivity: |
Human;Mouse;Rat |
| Alternative Names: |
Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] |
| Source: |
Rabbit |
| Dilutions: |
WB 1:1000-2000 |
| Immunogen: |
Synthesized phosho peptide around human IGF-I Receptor (Tyr980) |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
pro: 155kD, recetor beta: 95kD |
| GeneID: |
3480 |
| Human Swiss-Prot No: |
P08069 |
| Cellular localization: |
Cell membrane ; Single-pass type I membrane protein . |
| Background: |
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014], |
