| Product name: |
ITGA5 (heavy chain, Cleaved-Arg894) rabbit pAb |
| Reactivity: |
Human;Mouse |
| Alternative Names: |
Integrin alpha-5 (CD49 antigen-like family member E;Fibronectin receptor subunit alpha;Integrin alpha-F;VLA-5;CD antigen CD49e) [Cleaved into: Integrin alpha-5 heavy chain; Integrin alpha-5 light chain] |
| Source: |
Rabbit |
| Dilutions: |
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000 |
| Immunogen: |
Synthesized peptide derived from human ITGA5 (heavy chain, Cleaved-Arg894) |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
94 110kD |
| GeneID: |
3678 |
| Human Swiss-Prot No: |
P08648 |
| Cellular localization: |
Membrane; Single-pass type I membrane protein. Cell junction, focal adhesion . Cell surface . |
| Background: |
function:Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi’s sarcoma lesions.,similarity:Belongs to the integrin alpha chain family.,similarity:Contains 7 FG-GAP repeats.,subunit:Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5 and NISCH. Interacts with HIV-1 Tat. Interacts with RAB21., |
