| Product name: |
LGR5 rabbit pAb |
| Reactivity: |
Human;Mouse |
| Source: |
Rabbit |
| Dilutions: |
WB 1:500-2000 ELISA 1:5000-20000 |
| Immunogen: |
Synthesized peptide derived from part region of human protein |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
99kD |
| GeneID: |
8549 |
| Human Swiss-Prot No: |
O75473 |
| Cellular localization: |
Cell membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Rapidly and constitutively internalized to the trans-Golgi network at steady state. Internalization to the trans-Golgi network may be the result of phosphorylation at Ser-861 and Ser-864; however, the phosphorylation event has not been proven (PubMed:23439653). . |
| Background: |
The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015], |
