| Product name: |
LOK rabbit pAb |
| Reactivity: |
Human;Rat;Mouse; |
| Alternative Names: |
STK10; LOK; Serine/threonine-protein kinase 10; Lymphocyte-oriented kinase |
| Source: |
Rabbit |
| Dilutions: |
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000 |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from human STK10. AA range:491-540 |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
120kD |
| GeneID: |
6793 |
| Human Swiss-Prot No: |
O94804 |
| Cellular localization: |
Cell membrane ; Peripheral membrane protein . |
| Background: |
This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. [provided by RefSeq, Jul 2008], |
