Synthesized peptide derived from human protein . at AA range: 1970-2050
Storage:
-20C/1 year
Clonality:
Polyclonal
Isotype:
IgG
Concentration:
1 mg/ml
Observed Band:
314kD
GeneID:
987
Human Swiss-Prot No:
P50851
Cellular localization:
Cell membrane ; Single-pass membrane protein . Endoplasmic reticulum membrane ; Single-pass membrane protein . Golgi apparatus, trans-Golgi network membrane ; Single-pass membrane protein . Lysosome membrane ; Single-pass membrane protein .
Background:
The protein encoded by this gene is a member of the WDL-BEACH-WD (WBW) gene family. Its expression is induced in B cells and macrophages by bacterial lipopolysaccharides (LPS). The encoded protein associates with protein kinase A and may be involved in leading intracellular vesicles to activated receptor complexes, which aids in the secretion and/or membrane deposition of immune effector molecules. Defects in this gene are associated with the disorder common variable immunodeficiency-8 with autoimmunity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012],
