| Product name: |
MCR rabbit pAb |
| Reactivity: |
Human;Rat;Mouse |
| Source: |
Rabbit |
| Dilutions: |
WB 1:500-2000 ELISA 1:5000-20000 |
| Immunogen: |
Synthesized peptide derived from human protein . at AA range: 10-90 |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
108kD |
| GeneID: |
4306 |
| Human Swiss-Prot No: |
P08235 |
| Cellular localization: |
Cytoplasm. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein. Cytoplasmic and nuclear in the absence of ligand; nuclear after ligand-binding. When bound to HSD11B2, it is found associated with the endoplasmic reticulum membrane. |
| Background: |
This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009], |
