| Product name: |
NFATc2 rabbit pAb |
| Reactivity: |
Human;Mouse;Rat |
| Alternative Names: |
Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2;NFATc2;NFAT pre-existing subunit;NF-ATp;T-cell transcription factor NFAT1) |
| Source: |
Rabbit |
| Dilutions: |
IHC-p 1:50-200, ELISA 1:10000-20000 |
| Immunogen: |
Synthetic peptide from human protein at AA range: 640-700 |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
100kD |
| GeneID: |
4773 |
| Human Swiss-Prot No: |
Q13469 |
| Cellular localization: |
Cytoplasm. Nucleus. Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription. |
| Background: |
This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Apr 2012], |
