| Product name: |
Nuclear Receptor NR4A1 (Phospho-Ser351) Antibody |
| Reactivity: |
Human; Mouse; Rat |
| Alternative Names: |
Nuclear receptor subfamily 4 group A member 1 (Early response protein NAK1;Nuclear hormone receptor NUR/77;Nur77;Orphan nuclear receptor HMR;Orphan nuclear receptor TR3;ST-59;Testicular receptor 3) |
| Source: |
Rabbit |
| Dilutions: |
WB 1:500-2000, ELISA(peptide)1:5000-20000 |
| Immunogen: |
Synthesized pospho peptide derived from human Nuclear Receptor NR4A1 (Phospho-Ser351) |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
77kD |
| GeneID: |
3164 |
| Human Swiss-Prot No: |
P22736 |
| Cellular localization: |
Nucleus . Cytoplasm . Mitochondrion . Nuclear export to the cytoplasm is XPO1-mediated and positively regulated by IFI27 (PubMed:22427340). Translocation to the mitochondrion upon interaction with RXRA and upon the presence of 9-cis retinoic acid (PubMed:17761950). . |
| Background: |
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011], |
