| Product name: |
NUMB rabbit pAb |
| Reactivity: |
Human;Mouse;Rat |
| Alternative Names: |
NUMB; Protein numb homolog; h-Numb; Protein S171 |
| Source: |
Rabbit |
| Dilutions: |
WB 1:500-2000; IF/ICC 1:100-500;ELISA 1:5000-20000 |
| Immunogen: |
Synthesized peptide derived from the Internal region of human NUMB. |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
70kD |
| GeneID: |
8650 |
| Human Swiss-Prot No: |
P49757 |
| Cellular localization: |
Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Localizes to perinuclear endosomes in an AAK1-dependent manner. . |
| Background: |
The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016], |
