| Product name: |
p95/NBS1 (phospho-Ser343) rabbit pAb |
| Reactivity: |
Human;Mouse |
| Alternative Names: |
Nibrin (Cell cycle regulatory protein p95) (Nijmegen breakage syndrome protein 1) |
| Source: |
Rabbit |
| Dilutions: |
WB 1:1000-2000 |
| Immunogen: |
Synthesized phosho peptide around human p95 (Ser343) |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
85kD |
| GeneID: |
4683 |
| Human Swiss-Prot No: |
O60934 |
| Cellular localization: |
Nucleus . Nucleus, PML body . Chromosome, telomere . Chromosome . Localizes to discrete nuclear foci after treatment with genotoxic agents (PubMed:26438602, PubMed:10783165, PubMed:26215093). Acetylation of ‘Lys-5’ of histone H2AX (H2AXK5ac) promotes NBN/NBS1 assembly at the sites of DNA damage (PubMed:26438602). . |
| Background: |
Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. [provided by RefSeq, Jul 2008], |
