| Product name: |
PC-PLD3 rabbit pAb |
| Reactivity: |
Human;Mouse;Rat |
| Alternative Names: |
PLD3; Phospholipase D3; PLD 3; Choline phosphatase 3; HindIII K4L homolog; Hu-K4; Phosphatidylcholine-hydrolyzing phospholipase D3 |
| Source: |
Rabbit |
| Dilutions: |
Immunohistochemistry: 1/100 – 1/300. ELISA: 1/5000. Not yet tested in other applications. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from human PLD3. AA range:326-375 |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Molecular Weight: |
55kD |
| GeneID: |
23646 |
| Human Swiss-Prot No: |
Q8IV08 |
| Cellular localization: |
Endoplasmic reticulum membrane ; Single-pass type II membrane protein . Lysosome lumen . Early endosome membrane ; Single-pass type II membrane protein . Late endosome membrane ; Single-pass type II membrane protein . Golgi apparatus membrane ; Single-pass type II membrane protein . Endosome membrane ; Single-pass type II membrane protein . Localizes to ER-associated vesicles in differentiating myotubes (PubMed:22428023). The soluble form in lysosome arises by proteolytic processing of the membrane-bound form (PubMed:29386126). Colocalizes with APP in endosomes (PubMed:29368044). . |
| Background: |
This gene encodes a member of the phospholipase D (PLD) family of enzymes that catalyze the hydrolysis of membrane phospholipids. The encoded protein is a single-pass type II membrane protein and contains two PLD phosphodiesterase domains. This protein influences processing of amyloid-beta precursor protein. Mutations in this gene are associated with Alzheimer disease risk. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Apr 2014], |
