Programmed cell death protein 1 (Protein PD-1;hPD-1;CD antigen CD279)
Source:
Rabbit
Dilutions:
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Immunogen:
Synthesized peptide derived from human Pdcd-1 AA range: 80-130
Storage:
-20C/1 year
Clonality:
Polyclonal
Isotype:
IgG
Concentration:
1 mg/ml
Molecular Weight:
32kD
GeneID:
5133
Human Swiss-Prot No:
Q15116
Cellular localization:
Cell membrane ; Single-pass type I membrane protein.
Background:
This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008],
