| Background: |
function:Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases.,PTM:Phosphorylation of Thr-35 is required for activity.,similarity:Belongs to the protein phosphatase inhibitor 1 family.,subunit:Interacts with PPP1R15A., |
