| Product name: |
RCC1 rabbit pAb |
| Reactivity: |
Human;Mouse;Rat |
| Alternative Names: |
RCC1 CHC1 |
| Source: |
Rabbit |
| Dilutions: |
WB 1:500-2000,IHC-p 1:50-200 ELISA 1:10000-20000 |
| Immunogen: |
Synthetic peptide from human protein at AA range: 301-350 |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
45kD |
| GeneID: |
1104 |
| Human Swiss-Prot No: |
P18754 |
| Cellular localization: |
Nucleus . Chromosome . Cytoplasm . Predominantly nuclear in interphase cells (PubMed:12194828). Binds to mitotic chromosomes (PubMed:12194828, PubMed:17435751, PubMed:20668449). . |
| Background: |
disease:Patients with Raynaud disease produce antibodies that bind to RCC1.,function:Promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds to the chromatin. RCC1/Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA.,similarity:Contains 7 RCC1 repeats.,subcellular location:Becomes dispersed throughout the cytoplasm during mitosis., |
