| Product name: |
TCP-1 rabbit pAb |
| Reactivity: |
Human;Mouse;Rat |
| Alternative Names: |
TCP1; CCT1; CCTA; T-complex protein 1 subunit alpha; TCP-1-alpha; CCT-alpha |
| Source: |
Rabbit |
| Dilutions: |
Western Blot: 1/500 – 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Immunogen: |
Synthesized peptide derived from the Internal region of human TCP-1 . |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
60kD |
| GeneID: |
6950 |
| Human Swiss-Prot No: |
P17987 |
| Cellular localization: |
Cytoplasm, cytosol . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . |
| Background: |
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, three pseudogenes that appear to be derived from this gene have been found. [provided by RefSeq, Jun 2010], |
