| Product name: |
Tuberin (phospho Thr1462) rabbit pAb |
| Reactivity: |
Human;Mouse;Rat |
| Alternative Names: |
TSC2; TSC4; Tuberin; Tuberous sclerosis 2 protein |
| Source: |
Rabbit |
| Dilutions: |
Immunohistochemistry: 1/100 – 1/300. Immunofluorescence: 1/200 – 1/1000. ELISA: 1/5000. Not yet tested in other applications. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from human Tuberin/TSC2 around the phosphorylation site of Thr1462. AA range:1428-1477 |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
200kD |
| GeneID: |
7249 |
| Human Swiss-Prot No: |
P49815 |
| Cellular localization: |
Cytoplasm. Membrane; Peripheral membrane protein. At steady state found in association with membranes. |
| Background: |
Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008], |
