| Product name: |
XRCC1 rabbit pAb |
| Reactivity: |
Human;Mouse;Rat |
| Alternative Names: |
XRCC1; DNA repair protein XRCC1; X-ray repair cross-complementing protein 1 |
| Source: |
Rabbit |
| Dilutions: |
Western Blot: 1/500 – 1/2000. Immunohistochemistry: 1/100 – 1/300. ELISA: 1/10000. Not yet tested in other applications. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from human XRCC1. AA range:517-566 |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
70kD |
| GeneID: |
7515 |
| Human Swiss-Prot No: |
P18887 |
| Cellular localization: |
Nucleus . Moves from the nucleoli to the global nuclear chromatin upon DNA damage. . |
| Background: |
The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008], |
